> For the complete documentation index, see [llms.txt](https://pennprs.gitbook.io/pennprs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://pennprs.gitbook.io/pennprs/introduction.md).

# Introduction

<figure><img src="/files/OUd0NvV5UPkKodh7R1LV" alt=""><figcaption></figcaption></figure>

[PennPRS](https://pennprs.org/) offers a cloud-based ecosystem for PRS applications, including pseudo-training pipelines, data resources, and cloud computing capabilities to support large-scale PRS model training.&#x20;

PennPRS enables efficient online applications of pseudo-training methods, allowing users to upload or query GWAS summary statistics, submit jobs, and download trained PRS models. It provides a user-friendly framework for the global genetic research community, aiming to enhance the accessibility of PRS applications and address disparities in computational resources. Specifically, we develop end-to-end pipelines to support both [single-ancestry](https://pennprs.gitbook.io/pennprs/user-manual/single-ancestry-analysis) and [multi-ancestry](https://pennprs.gitbook.io/pennprs/user-manual/multi-ancestry-analysis) data analyses. More details of these pipelines are provided in the User Manual.&#x20;

The PennPRS Team&#x20;